With reference to the December 2025 breakthrough in computer-aided drug discovery, which key limitation of traditional Molecular Dynamics (MD) simulation does the novel open-source computational framework PathGennie primarily address?

Subject: General Awareness | Topic: Affairs | Difficulty: MEDIUM

Options

1. (A) Difficulty in realistically simulating rare unbinding events without including artificial bias forces
2. (B) Incompatibility of MD simulation with quantum chemical calculations
3. (C) Excessive memory consumption during protein structure prediction
4. (D) Inability to compute drug binding affinity under physiological pH

Verified Answer

Option (A): Difficulty in realistically simulating rare unbinding events without including artificial bias forces

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