Due to a rare genetic disorder the hard matrix of a particular type of connective tissue becomes less rigid, causing repeated fractures. What is the most likely explanation for this observation?

Subject: General Awareness | Topic: Science | Difficulty: MEDIUM

Options

1. (A) Deficiency of plasma proteins in the blood matrix
2. (B) Reduction of calcium and phosphorus compounds in the bone matrix
3. (C) Defect in type I collagen due to mutation in the COL1A1 or COL1A2 gene
4. (D) Loss of proteins and sugars in the cartilage matrix

Verified Answer

Option (C): Defect in type I collagen due to mutation in the COL1A1 or COL1A2 gene

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